Part 1 will be an initial drug dose + focused ultrasound energy escalation phase, where patients will be treated with two dose levels of SONALA-001 in combination with one of three dose levels of focused ultrasound as a single dose of SDT.

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Part 2 is a schedule escalation phase where 6 patients will be treated twice with SDT. Then 6 patients will be treated three times at the recommended dose from part 1.

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Part 3 will be an expansion cohort, where patients will be treated at the recommended SDT dose from part 1 and the recommended SDT schedule from part 2.

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For more details visit our ClinicalTrials.gov listing: https://www.clinicaltrials.gov/ct2/show/NCT05370508